Preconditioning PBM Therapy What Is That?
Preconditioning or wellness PBM Therapy is an exiting development in Photomedicine. Scientists have discovered that applying PBM Therapy – light in the Red and Near Infra Red (NIR) spectrum to ‘normal tissues/cells’ – cells that are not damaged or diseased:
Preconditioning has huge potential benefits in terms of health and wellness – how might maximising cell function benefit to your health?
Preconditioning PBM Therapy Keeping Tissues ‘Younger’
Long term Random Controlled Trials (RCT’s) to study human tissue cell damage/aging is not possible in real life as we age far too slowly (life span of 70+ years) and there are so many other factors during that time that could alter the results such diet, lifestyle and exercise. But long term RCT cell research is easily carried out on animals, usually mice as:
- Mice’s cells tissues and organs are physiologically and biochemically similar to humans (which is why they are used in drug/vaccine trials for humans)
- Mice age quickly – mice live about 1 year in the wild and a bit longer in captivity so they are ideal to use as their bodies age rapidly
- In lab RCT’s all the factors can be controlled so the ONLY difference between groups is whether they have PBM Therapy or not
Slowing Down The Signs Of Tissue Aging
Brain tissue is a really good way to measure cell and tissue aging. Why? As the brain ages it develops increased numbers of age related cells called Astrocytes and Microglia – these cells also collectively known as Glial Cells and the process of this aging is known as Gliosis. The greater the number of cells the greater the gliosis the greater age of the tissue – simple!
In this long term preconditioning PBM Therapy study brain cell aging in mice was studied over a 12 month period (which is about the the life expectancy of mice in the wild). The researchers created 3 groups (the group colour matches the results in the charts below).
- Control group 1 – 3 month old mice were killed* to determine the number of the glial cells when the mice are young to give a base line number with no PBM Therapy
- Control group 2 – 12 month old mice were killed* to determine the number of the glial cells when the mice are old at the end of the study with no PBM Therapy
- PBM Therapy group 3 had daily 20 minutes of PBM Therapy from the age of 5 months to 12 months (8 months = 210 days in a row). They were then killed* to determine the number of the glial cells when the mice are are old at the end of the study with PBM Therapy
*Brain tissue is extremely thinly sliced, stained with dyes to show the specific glial cells and then mounted on slides to be studied with powerful microscopes to be able to count the cells.